Table of Contents
Frontmatter FOREWORD Official Sponsors and Donors YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D Vitamin D Workshop. Career Recognition Awardees Contents Chemistry of Vitamin D Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships Chemical Conversion of Vitamin D3 to Calcitriol Lactone Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs Metallic Complexes of Hydroxylated Derivatives of Vitamin D3 A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D3 Structure-Activity Studies of Fluorinated Vitamin D Analogs An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion Synthesis of 24-Hydroxy-Vitamin D Analogues Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D3 A New Route to the Vitamin D Triene System Studies on the Synthesis of 19-Norprevitamin D3 Analogues Structure/Function Studies of Vitamin D Steroids The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications Future Prospects for Vitamin D Analogs Chemistry and Biology of 22,23-yne Analogs of Calcitriol Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells Synthesis and Biological Character of 1δ-Hydroxylated Vitamin D3 Analogs Biological Activity and Conformational Analysis of 1α,25-dihydroxyvitamin D3 and its Analogues Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto New Discoveries in Vitamin D Related Compounds Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region Synthesis and Biological Activity of 23-oxa Vitamin D Analogues Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues 20-Methyl Vitamin D Analogues 2δ-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs Vitamin D Binding Protein Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D3 Analogues Vitamin D Hydroxylases: Biochemistry and Regulation Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D3-Induced Expression of