Allergic Contact Dermatitis: Chemical and Metabolic Mechanisms

Allergic Contact Dermatitis: Chemical and Metabolic Mechanisms

by Camilla Smith
Allergic Contact Dermatitis: Chemical and Metabolic Mechanisms

Allergic Contact Dermatitis: Chemical and Metabolic Mechanisms

by Camilla Smith

eBook

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Overview

llergic Contact Dermatitis assesses the potential effects of xenobiotic metabolism and protein reactivity on toxicity. It reviews current knowledge of percutaneous absorption and skin metabolism and includes discussion of the xenobiotics themselves. It answers questions such as: How does sensitisation relate to protein reactivity and levels of metabolism? How we can identify potential hazards in food, cosmetics and pharmaceuticals etc?

In a world where people are becoming increasingly aware of their allergies, this up to date one-stop reference will prove an invaluable addition to the shelves of any researcher in academia, government, regulatory bodies, public health officials and, of course, the food, cosmetics and pharmaceuticals industries will find the book to be of particular relevance.


Product Details

ISBN-13: 9781000893779
Publisher: CRC Press
Publication date: 01/06/2023
Sold by: Barnes & Noble
Format: eBook
Pages: 336
File size: 19 MB
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About the Author

Camilla Smith (Levers Brothers, UK), Sharon Hotchkiss (Imperial College of Medicine, England, UK)

Table of Contents

1. Allergic Contact Dermatitis to Small Molecules 2. Percutaneous Penetration of Xenobiotics 3. Enzymes and Mechanisms of Xenobiotic Metabolism 4. Enzymes and Pathways of Xenobiotic Metabolism in Skin 5. Xenobiotics as Skin Sensitizers: Metabolic Activation and Detoxication, and Protein-Binding Mechanisms 6. Protein-hapten Binding and Immunorecognition Events During the Sensitisation and Elicitation Stages of ACD 7. Conclusion: Basic Considerations for Xenobiotic-Derived ACD and a Modified MHC-Peptide-Hapten Hypothesis
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